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Inbred strain
Inbred strains (also called inbred lines, or for animals linear animals) are individuals of a particular species which are nearly identical to each other in genotype due to long inbreeding. Inbred strains of animals are frequently used in laboratories for experiments where for reproducibility of conclusions all the test animals should be as similar as possible. However, for some experiments, genetic diversity in the test population may be desired. Thus outbred strains of most laboratory animals are also available.
Certain plants including the genetic model organism ''Arabidopsis thaliana'' naturally self pollinates, which makes it quite easy to create inbred strains in the laboratory (other plants, including important genetic models such as Maize require transfer of pollen from one flower to another). For most animals, the usual procedure is mating of brother-sister pairs for a minimum of 20 generations, which will result in lines that are roughly 99% genetically identical. Many inbred strains have been inbred for many more generations and are in effect isogenic.
== Effects ==
Inbreeding animals will sometimes lead to unwanted genetic drift. The continuous overlaying of like genetics exposes recessive gene patterns that often lead to changes in reproduction performance, fitness, and ability to survive. A decrease in these areas is known as inbreeding depression. A hybrid between two inbred strains can be used to cancel out deleterious recessive genes resulting in an increase in the mentioned areas. This is known as heterosis.
The best-known strains of laboratory animals are:
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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